Metformin hydrochloride, also known as Glucophage, is a medication used to treat type 2 diabetes. It belongs to the class of biguanides and works by reducing glucose production in the liver and increasing insulin sensitivity in the body.
It is commonly prescribed for patients who are unable to control their blood sugar levels with diet and exercise alone or those who have not achieved adequate glycemic control with other medications.
As mentioned earlier, metformin hydrochloride works by reducing glucose production in the liver and increasing insulin sensitivity. This is achieved through several mechanisms, including:
Inhibition of gluconeogenesis, a process that converts amino acids, lactate, and glycerol into glucose.
Increased expression of genes involved in glucose uptake and utilization in muscles and adipose tissue.
While metformin hydrochloride has been shown to be effective in managing type 2 diabetes, it is not without its limitations. Some common side effects include:
Nausea and vomiting
Diarrhea
Abdominal pain